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Lipids, curvature, and nano-medicine

Maekawa R, Mihara Y, Sato S, Okada M, Tamura I, Shinagawa M, et al

Interestingly, chronic supplementation with fucoidan mitigated the downregulation of BDNF-dependent synaptic plasticity by reducing caspase-1-mediated inflammation and substantially improving behavioral deficits associated with caspase-1 overexpression in the hippocampus of mice

Second, the hypoxic environment of the periodontal pocket directly upregulates expression of the fatty acid transporter CD36 via HIF-1, increasing cellular uptake of extracellular fatty acids and providing a more abundant substrate for ACSL4 (25, 26)